In the past decades, the morbidity and mortality of digestive system diseases are increasing at an alarming rate globally!it has also been found that digestive system diseases are the most important part of the combinations of either binary or tripartite chronic comorbidities, which has posed the heavy burden on global health.
As research progresses, researchers are gradually discovering that besides genetic susceptibility, lifestyles and the living environment, etc. all play an important role in digestive system diseases. Since one of the characteristics of digestive system diseases is the involvement of multiple factors in their development, meanwhile some studies are limited to the number of participants in their study cohorts , the number of indicators investigated and the follow-up time, the risk factors for digestive system diseases, their specific mechanisms, outcomes and prognosis of current treatment modalities remain to be confirmed in further research.
We plan to collaborate with clinicians, during the three years of the project, firstly, to elucidate the potential risk factors and their interactions among the development of digestive system diseases, then construct and verify the risk prediction models. Additionally, we will focus on the outcomes and prognosis of current modalities depending on the abundant and credible data especially the long-term follow-up data, to identify the subgroups who can derive significant benefit. Thirdly, we intend to explore multimorbidity networks and patterns in middle-aged and elderly patients with chronic diseases and to provide a new perspective and references for the management in this population.
We believe our research could elucidate further the risk factors, etiology, and mechanism of digestive system diseases, provide individualized prediction and treatment for patients, support the development of new disease management models, and ultimately promote human health and well-being.
