Metabolic diseases are a serious burden for human beings, and it is crucial to reveal the mechanisms and treatments of metabolic diseases. Unhealthy lifestyles, environmental factors, and genetic factors may lead to the development of metabolic diseases; metabolic diseases (e.g., NAFLD, II diabetes) are closely associated with the development of psoriasis, cardiovascular disease, and renal disease; and different treatment modalities may have different impacts on the outcomes, quality of life, and cost of patients with metabolic diseases. Therefore, we would like to utilize the UK biobank data to explore the possible etiology, diagnosis and treatment of metabolic diseases and their potential interactions with related diseases, and to develop effective prevention and treatment strategies on this basis.
We plan to explore the following questions:
1. Whether genetics, environment, lifestyle, demographic characteristics, and psychology have an impact on the onset and progression of metabolic diseases
2. Whether it is possible to combine several biomarkers or find new biomarkers to diagnose metabolic diseases.
3. How factors such as nutrition, lifestyle, psychology, and gut flora influence the development or treatment of metabolic diseases.
4. How metabolic diseases are related to each other and the causes of gender differences are still not fully understood.
5. Whether there is an association between metabolic diseases and other systemic diseases (e.g., sepsis, reproductive disorders, multiorgan failure)
6. Differences in outcomes, quality of life, and costs of different treatment modalities for patients with metabolic diseases.
We expect this project to last about 36 months and result in several publications.
The project will contribute to a better understanding of the causes associated with metabolic diseases and explore their potential impact on certain diseases. It will contribute to a more comprehensive understanding of metabolic diseases, as well as to the development of targeted prevention strategies and treatments.