This project aims to investigate the distribution and variation of C-reactive protein (CRP) levels across multiple disease cohorts using UK Biobank data. CRP, an inflammatory biomarker, is widely recognized for its role in the pathogenesis and progression of numerous diseases, including cardiovascular diseases, autoimmune disorders, and cancers. By analyzing CRP levels across various diagnosed cohorts, this study seeks to answer the following questions: 1) How do CRP levels vary across different diseases, and what patterns of distribution emerge when adjusted for demographic and lifestyle factors? 2) Are there specific CRP level thresholds that correlate with disease severity or risk progression?
The primary objective is to establish comprehensive CRP distributions across disease types to identify potential values for clinical endpoints and trial enrollement. Understanding CRP variability across populations may provide insight into inflammation-driven disease pathways and contribute to improved risk stratification and personalized treatment strategies. This research can enhance our scientific understanding of inflammation’s role in various pathologies and potentially guide preventive and therapeutic measures.