Stroke is a leading cause of morbidity and mortality worldwide, yet the underlying genetic and environmental factors influencing its development remain poorly understood. This research aims to investigate the genetic and environmental factors associated with the risk of stroke using data from the UK Biobank.
Research Questions:
What genetic factors are associated with an increased risk of stroke?
How do environmental factors (such as smoking, alcohol consumption, physical activity, and diet) influence the development of stroke?
What is the interaction between genetic and environmental factors in determining stroke risk?
Objectives:
To conduct a genome-wide association study (GWAS) to identify genetic variants linked to stroke.
To analyze environmental and lifestyle data from the UK Biobank to assess their impact on stroke development.
To investigate potential gene-environment interactions that may increase susceptibility to stroke.
Scientific Rationale: Understanding the genetic and environmental factors contributing to stroke can provide valuable insights into its pathophysiology, enable early identification of high-risk individuals, and improve prevention strategies. By utilizing the extensive genomic, clinical, and lifestyle data available in the UK Biobank, this research will help identify novel genetic markers and environmental risk factors associated with stroke. Ultimately, this study aims to improve stroke risk assessment, early diagnosis, and personalized treatment options, leading to better patient outcomes.