Research questions
(a) How do different aspects of the environment-such as natural, built, and social environments-together with genetic factors, shape mental, cognitive, and physical health across the lifespan?
(b) What are the key biological and neural pathways linking external environments to health outcomes?
(c) How do individual differences contribute to vulnerability or resilience in these processes?
Objectives
This project is conducted as part of a postgraduate academic course, led by a student researcher under the supervision of the principal investigator. The objectives are to:
(a) Develop an integrative framework connecting environmental influences (including natural, built, and social dimensions), biological mechanisms, and health outcomes.
(b) Examine how brain characteristics may serve as intermediaries between environmental exposures and health trajectories.
(c) Explore how genetic background modifies these associations.
(d) Identify population subgroups that are particularly sensitive to environmental influences, supporting more tailored prevention strategies.
Scientific rationale
Rapid demographic and environmental changes have contributed to rising mental and physical health challenges. Yet, most research focuses on single exposures or outcomes, overlooking the complex interplay among biological, environmental, and social factors. This project will take advantage of the comprehensive and longitudinal nature of the UK Biobank to examine how multiple influences interact to affect health and wellbeing. By integrating information across biological and environmental domains, the study aims to provide a more holistic understanding of health determinants and to inform strategies that support healthier ageing and living environments.