Common diseases in the field of otolaryngology involve multiple organ systems and various types, including allergic rhinitis, chronic rhinosinusitis, acute and chronic laryngitis, vocal cord polyps, laryngeal malignancies, pharyngeal malignancies, middle ear cholesteatoma, sudden sensorineural hearing loss, and Meniere’s disease. The incidence of these diseases has been rising annually, imposing significant economic burdens and lifestyle disruptions on individuals and countries worldwide. However, our understanding of the multifactorial etiology of common otolaryngological conditions remains limited. We intend to utilize the comprehensive dataset from UK Biobank to conduct multi-omics analyses, aiming to explore and address several critical research questions. Our objective is to elucidate the complex interplay between genetic predisposition and environmental factors, such as individual lifestyle choices (diet, sleep, smoking, physical activity, etc.). Ultimately, we seek to identify and develop clinically significant strategies to facilitate the early detection, precise diagnosis, and personalized treatment of common otolaryngological diseases, thereby improving patient outcomes and reducing the global impact of these conditions.
