Oral diseases not only cause localized pain and impaired chewing function but may also affect overall health through pathways such as blood circulation and nerve transmission (e.g., cardiovascular and cerebrovascular diseases, diabetes, digestive system disorders), making them a major global public health concern. Their pathogenesis involves multifactorial characteristics, influenced by genetic susceptibility, environmental exposure, behavioral factors, socioeconomic conditions, and microbial imbalance.
UK Biobank provides large-scale long-term cohort data (phenotypes, genomes) to explore these interactions; genomic tools (GWAS, QTL), Transcriptome-wide association studies (TWAS) and multimodal research!gene regulation!, and machine learning (risk screening, causal inference, personalized prediction) enable in-depth analysis, supporting precision prevention/treatment.
Research Questions
1)Which behavioral, environmental, socioeconomic, genetic (multi-omics), and microbiome factors can predict the onset and prognosis of oral diseases?
2)How do these factors interact to influence disease progression and complications?
3)which mechanisms do oral diseases interact with other organ systems to trigger the coexistence of multiple diseases?
4)Which modifiable factors and genetic determinants jointly influence the occurrence of oral diseases and their comorbidities?
Research Objectives: Identify predictive factors for oral diseases/comorbidities. Elucidate molecular mechanisms of disease progression. Assess multimorbidity via systemic association analysis. Infer causal relationships between factors and diseases. Unravel key genetic variants. Discover genetic correlations between oral diseases and comorbidities. identify drug repurposing targets. Develop clinical predictive models.
This study aims to decode oral disease complexity and systemic links, advancing precision medicine.
