Non-communicable chronic diseases (NCDs) have become a major health burden worldwide, with disability and mortality rates particularly high in middle- and high-income countries. Although numerous studies have investigated the causes of NCDs, effective, comprehensive intervention strategies to curb their progression remain lacking. The etiology of NCDs is complex, involving multifactorial influences from lifestyle, dietary habits, and environmental exposures. Consequently, systematic multi-omics analyses are essential for a more nuanced understanding of these interacting factors. This study aims to leverage data from the UK Biobank, integrating lifestyle, dietary, anthropometric, environmental exposure, and clinical multi-omics information to explore multiple risk factors for NCDs. The specific objectives are as follows: 1)Identifying Key Lifestyle and Dietary Factors Associated with NCDs: Through analyzing lifestyle and dietary data, we aim to uncover behavioral patterns closely linked to NCDs, providing a basis for targeted health interventions. 2)Assessing the Risk Impact of Environmental Exposures on NCDs: By combining environmental exposure data, we will quantify the effects of various environmental factors to elucidate their roles in NCD development. 3)Developing a Multifactorial Risk Prediction Model for NCDs: Using anthropometric and clinical omics data, we will construct a multilayered risk model to support the formulation of personalized prevention strategies.
