This project aims to investigate associations between circadian rhythm disruptions and neuroimmune disorders (NMOSD, MS, MOGAD) using UK Biobank data.
Research questions: Do circadian disruptions (sleep irregularities, shift work, genetic variants) increase disease risk or severity? How do circadian clock genes contribute to these disorders?
Objectives: (1) Assess links between behavioral circadian disruptions (sleep patterns, shift work) and disease risk. (2) Examine genetic contributions of circadian-related genes (e.g., CLOCK, BMAL1). (3) Explore impacts on disease progression (relapse rates, disability).
Rationale: Circadian rhythms regulate immune homeostasis and CNS function. Disruptions (environmental or genetic) may exacerbate neuroinflammation, a hallmark of NMOSD/MS/MOGAD. The UK Biobank’s rich data on sleep, genetics, and clinical outcomes enables robust analysis of these interactions, addressing gaps in understanding disease triggers and progression.
