Research Question
This study examines individual/environmental factors and neurobiological mechanisms underlying chronic constipation in adults aged !50, addressing critical gaps in elderly-specific pathophysiology research. Affecting 15%-20% of elderly populations globally, chronic constipation elevates cardiovascular risks and reduces quality of life through physical-psychological comorbidities. The research investigates interactions between genetic predisposition, dietary habits, mental health, social engagement, socioeconomic status, and central nervous system regulation via structural brain MRI.
Research Objectives
Current studies predominantly focus on isolated factors rather than gene-environment interactions or neuro-gut axis dysfunction. This multimodal approach systematically analyzes how socioeconomic disparities intersect with biological vulnerabilities, particularly examining anxiety-constipation bidirectional relationships and neuroanatomical biomarkers. Brain imaging targets neural correlates of gut motility regulation, distinguishing age-related mechanisms from younger populations.
Scientific Rationale
The scientific rationale emphasizes addressing global aging challenges, as chronic constipation represents a multi-system disorder extending beyond gastrointestinal dysfunction. By integrating epidemiological data with neuroimaging evidence, the study aims to advance personalized interventions, including neuromodulation therapies and prevention frameworks. Findings seek to establish evidence for geriatric care improvements, focusing on how central nervous system alterations contribute to constipation pathology and its management. Ultimately, this research bridges gaps in understanding neurobiological pathways and socioeconomic determinants within elderly constipation development, informing targeted healthcare strategies.
