This study aims to explore how genetic factors, hematological markers, and environmental exposures influence the development, progression, and metastasis of cancer, as well as resistance to cancer treatments. Cancer is a complex disease driven by a variety of intrinsic and extrinsic factors, including genetic mutations, inflammatory processes, and environmental exposures such as pollution, diet, and lifestyle. Resistance to cancer therapies, whether due to genetic mutations or environmental influences, remains one of the biggest challenges in cancer treatment. The research will investigate how genetic mutations and hematological factors interact with environmental exposures to contribute to cancer onset and progression, and examine the role of inflammatory markers and cytokines in cancer metastasis and therapy resistance. Additionally, the study will explore how environmental exposures, such as pollution and occupational hazards, influence treatment efficacy and resistance. Using multi-dimensional models, the research aims to identify predictive biomarkers for cancer prognosis and therapy response. The study will also examine the impact of lifestyle factors, such as diet and smoking, on cancer progression and resistance to therapies. By providing comprehensive insights into how a combination of genetic, hematological, and environmental factors influences cancer development and treatment response, this research seeks to improve personalized cancer treatment and prevention strategies.