Research Questions:
1.What are the shared immune-inflammatory genetic susceptibilities between intracranial aneurysms and other cardiovascular diseases?
2.How do epigenetic mechanisms regulate the immune-inflammatory responses in the pathogenesis of intracranial aneurysms and their association with other cardiovascular diseases?
Objectives:
1.To identify the key genes and proteins involved in the immune-inflammatory pathways that are commonly associated with intracranial aneurysms and other cardiovascular diseases.
2.To explore the epigenetic regulation of these immune-inflammatory genes and their impact on the development and progression of intracranial aneurysms.
3.To investigate the metabolic characteristics of the microenvironment in intracranial aneurysms and their relationship with the immune-inflammatory responses.
Scientific Rationale:
Intracranial aneurysms share common pathological features with other cardiovascular diseases, such as endothelial dysfunction, inflammation, and vascular remodeling. Previous studies have shown that immune-inflammatory responses play a crucial role in the development and rupture of intracranial aneurysms. However, the shared genetic and epigenetic mechanisms underlying these processes are not fully understood. This study aims to fill this knowledge gap by using a multi-omics approach, including genome-wide association studies, transcriptome analysis, and epigenetic profiling, to identify the key genes, proteins, and pathways involved in the immune-inflammatory responses in intracranial aneurysms and their association with other cardiovascular diseases. The findings of this study will provide new insights into the pathogenesis of intracranial aneurysms and may lead to the development of novel therapeutic strategies for the prevention and treatment of this condition.
