Genetic architecture and environmental risk factors of women’s reproductive disorders and their adverse health implications

Risk factors for complex diseases such as reproductive disorders mainly derive from genetic susceptibility and modifiable environmental factors, such as smoking, drinking, physical activities, etc. Meanwhile, the large short-term and long-term health implications caused by women’s reproductive disorders have been raised attention in the fields of cardiovascular disease, cognitive dysfunction, neurology system disease, and mortality although the underlying mechanisms have not been fully elucidated. Therefore, we aim to 1) identify genetic, environmental, and their joint effects on reproductive disorder onset and progress, including menarche, menopause, sex hormone use, pregnancy, miscarriage, infertility, polycystic ovary syndrome, endometriosis, etc., and 2) investigate their adverse health effects in neurology system. We expect the duration of this project to be 36 months. Identification of the effects of genes, environment, and their joint effect on the reproductive disease would allow us not only to better understand disease development but can also bring about opportunities for primary prevention to avoid disease onset.