Aims: Our study aims to identify any potential shared genetic architecture that may underlie the multimorbidity that exists between CVD and other multiple chronic diseases. Scientific rationale: In the twenty-first century, population aging is a major public health issue worldwide, and multimorbidity of multiple chronic diseases is a common problem that arises as a result of population aging, especially the common multimorbidity between CVD and other chronic diseases in the elderly population. In addition to common environmental risk factors, shared genetic factors can also contribute to multimorbidity. Previous research has revealed the genetic overlap of CVD and some other chronic diseases, such as AD. However, the multimorbidity studied in the past concentrated on a limited number of disorders, and knowledge of the shared genetic basis and the mechanism behind multimorbidity is still restricted. Therefore, conducting a comprehensive study on the shared genetic architecture of multimorbidity and its underlying mechanisms will deepen our understanding of the pathogenesis and progression of multimorbidity. Project duration: We plan to accomplish some initial milestones in the next 3 years. Public health impact: Our research has important implications for risk prediction, risk management, prevention, and treatment of multimorbidity. By concentrating on the shared environmental risk factors, our research may advance public health policy priorities. Evidence on shared genetic architecture will aid in understanding the genetic basis and biological mechanism of multimorbidity in chronic diseases. All these findings may inform healthcare providers to supply more efficient treatment in precision medicine.
