This project aims to identify genetic variants associated with the progression from DVT to PTS. DVT is a common vascular condition, and approximately 20-50% of individuals subsequently develop PTS, a chronic and disabling complication. Although several clinical risk factors have been described, the genetic mechanisms underlying progression to PTS remain unclear.
The primary research questions are:
1. Which genetic variants are associated with the risk of developing PTS following DVT?
2. Can a genetic risk profile help identify individuals with increased susceptibility to disease progression?
A genome-wide association study (GWAS) will be performed in UK Biobank participants with an incident DVT diagnosis, comparing those who develop PTS during follow-up with those who do not. Results may offer insight into novel biological pathways involved in venous disease progression and inform predictive risk models.
