Research Question
The core research question of this study is to investigate the genetic and biological foundations of psychological and behavioral traits, with a particular focus on how genetic variations influence the onset and development of mental health disorders. Specifically, the study aims to explore which genetic variations are associated with common psychological traits such as cognition, emotional regulation.Although genome-wide association studies have successfully identified genetic links to certain psychiatric disorders, relatively little research has been conducted on the genetic architecture of everyday psychological traits and their relationship to mental health. This study seeks to extend prior research by employing GWAS, Mendelian randomization, and structural equation modeling to connect genetics with behavioral and mental health outcomes.
Objectives
1. Identify genetic variants associated with psychological traits and mental disorders using large-scale GWAS.
2. Establish causal relationships between genetics and behavior using Mendelian Randomization.
3. Investigate genetic mechanisms affecting cognition, emotion, and behavior through multi-level models.
4. Foster interdisciplinary integration of genomics, psychology, and neuroscience.
Scientific Rationale
Psychological behaviors are influenced by complex genetic and environmental factors, yet the biological mechanisms remain unclear. This study will leverage the UK Biobank’s large-scale genomic and phenotypic data to identify genetic variants associated with psychological traits and mental disorders. By applying GWAS and Mendelian Randomization, we aim to establish causal links between genetics and mental health, offering new insights for precision medicine and mental health interventions. This research will advance understanding of mental health at both biological and population levels, supporting public health strategies and improving clinical practice.