The purpose of this study is to identify the polymorphisms showing sex-genotype interaction effects on brain imaging and cognitive phenotypes.
Utilizing the huge sample size, a recent study (Eliott et al., 2018, Nature) revealed the clusters of associations between polymorphisms and brain imaging phenotypes. Similarly, using the huge sample size, a recent study (Davies et a., 2018, Nature Communications) revealed the number of associations between polymorphisms and general cognitive functions.
On the other hand, previous studies of polymorphisms, revealed the sex-genotype interaction effects on brain and cognitive mechanisms. (e.g., Takeuchi et al., 2018, Cerebral Cortex). Further, these sex-specific genetic architectures are seen in across a spectrum of human complex traits.However, previous genome wide associations studies have generally not identified the SNPs that show the sex-interaction effects on neural mechanisms and cognitive mechanisms which is the purpose of this study.
Project duration is expected to be as long as 36 months.
The genetic bases of brain mechanisms and cognitive functions are of utmost scientific and social interest, and revealing sex differences of these and elucidating genetic architectures of brain mechanisms and cognitive functions are also of utmost scientific and social interest. Identification of sex-specific genetic mechanisms of brain mechanisms and cognitive functions can give insights into the prevention of maladaptive neurocognitive development and also important for public health.
