Hematologic malignancies in process/plant and machine operatives have been reported sporadically, but a large-scale prospective cohort study has not been conducted. This study could provide valuable insight regarding the increased incidence of hematologic malignancies in process/plant and machine operatives. This study aims to determine which specific occupations in process/plant and machine operatives pose a greater risk of hematologic malignancies than typical occupations. The expected duration of the project is one year. Using the results of this project, we can suggest a more efficient hematologic cancer prevention strategy for process/plant and machine operatives.