Purpose: This research aims to investigate the heterogeneity, complications, therapeutic responses, and long-term outcomes of inflammatory skin diseases, particularly psoriasis, atopic dermatitis (AD) , alopecia areata and drug eruption. The study focuses on identifying the factors influencing these conditions through a multi-omics and epidemiological approach.
Scientific Rationale: Inflammatory skin diseases, such as psoriasis, AD, alopecia areata and drug eruption, significantly affect patients’ quality of life and place substantial burdens on healthcare systems globally. Psoriasis is a chronic immune disorder affecting multiple systems, while AD is associated with mental health issues like depression and anxiety and increased risks of cardiovascular disease. Alopecia areata, traditionally viewed as a Th1-mediated inflammatory disease, is now understood to involve the Th2 pathway as well, indicating a shared pathogenic mechanism with AD. This disease also correlates with anxiety and depression. The pathogenesis of drug eruption involves both Th1 and Th2 pathways. Despite significant research efforts, the underlying mechanisms driving the heterogeneity and complications remain poorly understood. Existing treatments for inflammatory skin diseases also have problems such as poor efficacy in some patients and easy relapse after treatment., necessitating a deeper understanding of the disease mechanisms to improve therapeutic strategies.
Methods: This study will employ multi-omics techniques, including genomics, proteomics, and metabolomics, to dissect the molecular mechanisms behind the heterogeneity and complications and varied treatment outcomes in inflammatory skin diseases. By integrating these biological factors with environmental and lifestyle factors obtained from epidemiological data, the project aims to elucidate how these elements collectively influence disease progression and treatment responses.
Duration: This project is planned to span three years.
Impact on Public Health: The findings from this research are expected to provide critical insights into the molecular underpinnings of inflammatory skin diseases, leading to better diagnostic tools and more effective, personalized treatment options. By investigating the complex interactions between genetic, molecular, and environmental factors, this study has the potential to significantly improve patient care and outcomes, ultimately reducing the healthcare burden associated with these inflammatory skin diseases.