Research question: How does the Apolipoprotein E gene variant contribute to early brain network disruption in Alzheimer’s disease?
Scientific rationale: Alzheimer’s disease causes a gradual loss of memory and thinking ability. Before symptoms appear, communication between different brain regions begins to weaken-a process known as functional disconnection. The brain normally relies on strong, coordinated networks to support learning, memory, and attention. When these connections fail, cognitive decline follows. The Apolipoprotein E gene variant is the strongest known genetic risk factor for late-onset Alzheimer’s disease. It is linked to greater buildup of harmful proteins, inflammation, and brain cell damage. However, we still do not fully understand how Apolipoprotein E affects functional connectivity and whether this disruption marks the earliest stages of neurodegeneration. Using resting-state functional MRI data from large-scale studies such as the UK Biobank, this project will examine how Apolipoprotein E influences the integrity of brain networks. By comparing people who carry Apolipoprotein E with those who do not, we aim to identify early patterns of network weakening that signal vulnerability to Alzheimer’s disease.
Aims: Aim 1: Identify brain networks most affected by early neurodegeneration.
Aim 2: Determine how the Apolipoprotein E alters functional connectivity and accelerates network decline.
