1.Research Question
Explore the association between 2940 plasma proteins and the risk of lung cancer development, identify the proteins with causal effects among them, and screen for potential early diagnostic biomarkers and therapeutic targets.
2.Research Objectives
(1)Identify plasma proteins significantly associated with lung cancer and its subtypes (lung adenocarcinoma, lung squamous cell carcinoma);
(2)Verify the causal relationship between these proteins and lung cancer, while excluding confounding factors and reverse causation;
(3)Preliminarily explore the mechanism of action of core proteins and their druggability potential.
3.Scientific Rationale
Lung cancer has persistently high incidence and mortality rates, and improving early diagnosis rates can effectively alleviate this predicament. As easily accessible biomarkers, plasma proteins have unique advantages in disease early warning and mechanistic research. Most existing studies are limited to small samples or a small number of proteins. The 2940 plasma protein datasets and long-term follow-up cohort provided by UKB-PPP offer an excellent resource for the systematic analysis of the association between proteins and lung cancer. This can address the limitations of current research and provide new clues for the precision prevention and control of lung cancer.
