Mental disorder, such as schizophrenia and depression, troubled patients with more than torment on the psychological, but reduced of immunologic function. Many researcher and doctor found the correlation between the mental disorder and autoimmune disease with their rich clinical experience. Here we build up a new scientific project with new genetic method and big data analysis, to investigate the connection between mental disorders and autoimmune diseases, in order to solve the problem that why these two kinds of diseases are always happened coincidence. We planned to spend 12 month on this project to reveal the inner connection between the two kinds of diseases which can make contribution to clinic work and disease precautions.