1. Research questions, objectives
This project aims to investigate the associations between genetic, lifestyle, social, and environmental factors and the risk of developing musculoskeletal disorders. Furthermore, we will examine the contribution of these factors to the progression from primary musculoskeletal disorders to common geratic comorbidities, such as cardiovascular diseases, cancers, and metabolic syndromes. By identifying key risk factors and vulnerable subpopulations, this study will enhance the understanding of disease pathogenesis and provide a scientific basis for the development of targeted strategies for early prevention and intervention.
2. Scientific rationale for the research
As the global population structure irreversibly trends towards aging, the incidence of age-related musculoskeletal disorders (such as osteoporosis, osteoarthritis, and sarcopenia) is expected to increase exponentially, leading to reduced quality of life, functional impairment, and increased mortality. Emerging evidence indicates that musculoskeletal disorders often co-occur with various other conditions, including cardiovascular diseases and metabolic syndrome, forming complex multimorbidity patterns. However, the underlying mechanisms linking musculoskeletal disorders with their comorbidities remain poorly understood and require in-depth investigation.
This study will leverage the extensive data resources of the UK Biobank to adopt a comprehensive, longitudinal research approach aimed at systematically exploring both modifiable and non-modifiable risk factors contributing to the onset and progression of musculoskeletal disorders and their related comorbidities. A deeper understanding of the complex interactions among genetic background, lifestyle, psychosocial factors, and environmental exposures is crucial for improving early risk prediction, guiding targeted prevention strategies, and advancing the development of personalized intervention plans.
