Identifying the potential effects of environmental and other healthcare related factors influencing health outcomes, mediated by genetic variances

Current studies have found that certain environmental factors and key health-care-related factors are associated with multiple health outcomes, while most of the previous articles are ecological study which difficult to explain the results due to the potential for ecological fallacy and the inability to control for confounding. From the perspective of precision medicine, it is necessary to explore the relationship between environment and key healthcare related factors and health outcomes at the individual level. Existing evidence suggests that environment and healthcare-related factors affecting individual health. Meanwhile, most diseases involve many genes in complex interactions, in addition to environmental influences.The purpose of this study is to explore the potential intermediaries between genetic variation in the environment, health care, and health outcomes, and to identify environmental factors and health care-related determinants that affect health outcomes. The purpose of this study is to explore the potential intermediaries between genetic variation in the environment, health care, and health outcomes which includes chronic diseases(for example, cancer, diabetes,mental illness, neurodegenerative diseases, mood disorders, respiratory diseases such as asthma and chronic obstructive pulmonary diseases, cardiovascular diseases such as coronary heart disease and stroke, autoimmune disease, occupational diseases, overweight and obesity, arthritis and osteoporosis, eye disorders, sleep disturbances and chronic pain), perceived general and mental health, life expectancy, all-cause mortality and cause-specific mortality, recovery from illness, and to identify environmental factors and health care-related determinants that affect health outcomes. This work may also provide clues to the development of safe and effective treatments by identifying ways in which environmental exposure and inadequate health services lead to disease, allowing health care professionals, environmental scientists and policy makers to make more informed decisions in their daily work.