The intended research will examine the impact of eating disorder history on fertility-related hormones in women of reproductive age, with a focus on the role of nutrition in effecting reproductive health outcomes. Eating disorders, including anorexia nervosa and bulimia nervosa, often involve chronic nutritional deficiencies and energy imbalances that can disrupt endocrine regulation. Insufficient intake of macronutrients and micronutrients may lead to menstrual irregularities, altered ovulation, and infertility. While it is well established that malnutrition from eating disorders can disrupt reproductive function, less is known about how these nutritional disruptions relate to fertility-specific hormones.
This study will use UK Biobank data to identify women with a history of eating disorders and compare them to women without. Key fertility-related hormones aiming to be examined include estradiol, progesterone, luteinizing hormone, and follicle-stimulating hormone, as well as relevant nutritional and anthropometric indicators such as body mass index and dietary intake measures. Statistical analyses will assess correlations between eating disorder history, nutritional status, and hormone profiles, adjusting for age, lifestyle, and comorbidities when necessary.
By utilizing the large UK Biobank dataset, this project will provide a comprehensive assessment of how nutritional disruption from eating disorders influences reproductive hormones across the reproductive years. Findings will advance understanding of the biological and nutritional mechanisms linking eating disorders to fertility challenges, offering insights for prevention, early intervention, and clinical care. Ultimately, this work aims to establish knowledge and strategies that support optimal reproductive health in women with a history of disordered eating.