Research Objectives:
– To explore the impact of metabolic risk factors and kidney disease on the incidence of cardiovascular disease.
– To explore the role of metabolic risk factors and kidney disease in the progression and prognosis of cardiovascular disease.
– To screen the key molecular targets that affect the development of cardiovascular diseases by metabolic risk factors and clarify their molecular mechanisms.
– To evaluate the role of selected key molecules in the prevention and management of cardiovascular disease.
Research Content:
– Determine the impact of metabolic and kidney diseases on the incidence of cardiovascular diseases, which involves using data on blood glucose, blood lipids, blood parameters, thyroid function, kidney-related indicators, and the incidence and specifics of various cardiovascular events.
– Evaluate the effect of metabolic and kidney diseases on the progression and prognosis of cardiovascular diseases, which includes data on blood glucose, blood lipids, blood parameters, thyroid function, kidney-related indicators, and indicators of cardiovascular event progression (such as death, major adverse cardiovascular events, recurrent cardiovascular events, cardiovascular disease exacerbation, and biochemical markers).
– Explore the associations between metabolic risk factors, kidney diseases, and cardiovascular diseases using whole-genome sequencing data from UKB. Identify differentially expressed genes related to metabolic factors and kidney diseases and investigate their potential functional roles in cardiovascular diseases. Perform enrichment analysis to explore the biological processes, pathways, and functional annotations associated with metabolic factors and kidney diseases concerning cardiovascular diseases. Assess the potential interactions between metabolic factors, kidney function, and cardiovascular disease development.