1. When there are multiple exposures, e.g., lifestyle (smoking, alcohol drinking, and physical activity), environment variable (air pollutants and climate), and metabolites (blood pressures, glucose, and lipids)? what is the association between them and health outcomes including cardiovascular, respiratory, metabolic, and mental health diseases. Whether there are one or more interaction effects including additive interaction or modification effects.
2. Which gene types are susceptible to exposures, and how these gene-exposure interactions are modified through transcriptional regulation, protein expression, and other multi-omics factors including lipids and enzymatic activities.
3. Which metabolic profiles, including biomarkers in body fluids and NMR-based measurements, are associated with various health outcomes? Additionally, are these metabolic factors mediators in disease pathways, interact with genetic and proteomic elements, and how can pathway analysis elucidate their roles within complex multi-omics networks?
We aim to investigate the associations between multiple exposures and metabolic markers and various health outcomes. Additionally, we will identify gene types sensitive to exposures and analyze how these associations are modified through transcriptional regulation, protein expression, and metabolic pathways within a multi-omics framework. Furthermore, we will elucidate the roles of metabolites within complex multi-omics networks.