Research Aims: This study will explore how biomolecular factors (genetic, protein, and metabolite profiles), behavioral patterns, and environmental factors influence the development and prognosis of cardiovascular diseases (CVD), including stroke. The aim is to identify therapeutic targets and support early prevention strategies and personalized clinical management.
Scientific Rationale: CVD, including stroke, are leading global causes of death, responsible for 32% of fatalities, according to WHO. In the UK, stroke accounts for 11% of deaths and contributes to long-term disability, costing the NHS over £8 billion annually. This burden underscores the need for better prevention and management strategies.
While lifestyle factors also play a role in disease onset and progression. However, the interaction between genetic, behavioral, and environmental factors is less understood. Investigating these complex relationships will help uncover how they drive disease risk.
Previous studies have highlighted genetic predispositions, but comprehensive research is needed to understand how these genes interact with lifestyle and environmental exposures. The UK Biobank provides an opportunity to address these knowledge gaps by integrating genomic, biomarker, and lifestyle data from a large, diverse population. Identifying modifiable risk factors and their biological interactions is key to improving screening, prevention, and treatment strategies.
Project Duration: Three years.
Public Health Impact: By identifying modifiable risk factors and biomarkers, This research will guide evidence-based prevention strategies to reduce disease incidence and improve outcomes.
The findings are expected to inform public health policy, especially interventions targeting high-risk populations, promoting healthier lifestyles, and reducing disparities. Addressing these issues could result in significant reductions in disease prevalence, healthcare costs, and improved public health outcomes.
