Aims: In this study, we aim to examine the association between environmental exposures, lifestyles, genetic variants, and early-onset diseases and late-onset diseases using the large-scale longitudinal datasets in UK Biobank.
Scientific rationale: Many studies have found that there are significant differences between early-onset diseases and late-onset diseases from the perspective of environmental exposure, lifestyles, and genetic factors. Identification of these distinctions is critical for developing targeted prevention strategies, personalized treatments, and effective public health policies.
Project duration: We anticipate the project duration to be 36 months.
Public health impact: The proposed study will contribute to a deeper understanding of the etiology of early-onset and late-onset diseases from collective and individual levels. It will utilize the comprehensive and robust UKB dataset to identify key differences in their genetic and environmental risk factors, ultimately informing better clinical practices and public health strategies to develop feasible strategies, personalized treatments, and effective public health policies.