Research questions!
1. What are the associations between sarcopenia and chronic/mental diseases such as diabetes, cardiovascular diseases, and depression?
2. What are the molecular mechanisms underpinning these associations?
3. Can novel or repurposed drugs be identified to treat sarcopenia, particularly in patients with comorbidities?
4. What lifestyle, nutritional, or clinical interventions could improve health outcomes and slow sarcopenia progression?
Objectives!
1. To investigate the associations between sarcopenia and chronic diseases/mental disorders, and to identify the sociological, physiological, and metabolic factors influencing these associations.
2. To explore the molecular mechanisms (genetic loci, signaling pathways, and biomarkers) of sarcopenia using multiomics (genomic, proteomic, metabolomic) approaches.
3. To conduct drug repurposing analysis for sarcopenia to suggest treatments for clinical use.
4. To evaluate lifestyle and clinical interventions to optimize prevention and management strategies for sarcopenia.
Scientific rationale!
Sarcopenia is a complex condition associated with multiple chronic diseases and mental disorders , significantly reducing quality of life and increasing healthcare burdens. Many of these associations are not adequately understood at the molecular level, limiting the development of effective interventions. By leveraging rich data from UK Biobank, this research will provide insights into the pathogenesis of sarcopenia and how sarcopenia interplays with various factors. The findings will inform early diagnosis, targeted treatments, and personalized management strategies, directly benefiting public health.