Aim: This project seeks to uncover novel insights into the pathophysiology and adverse effect of hearing loss, tinnitus and sleep related nero- and cardiometabolic disorders.
Scientific rationale: Hearing loss creates communication barriers that can lead to social isolation. This can cause anxiety, depression, and a variety of other negative outcomes. Tinnitus also has a significant impact on sleep and psychology. But it’s not yet clear exactly what kind of adverse health effects hearing loss and tinnitus could have. In addition, there is a lack of in-depth pathophysiologic research on the prevention and treatment of the aforementioned disorders.
Procedure: This study aims to utilize an integrative multi-omics approach, combining genetic, metabolic, and proteomic data with environmental exposures and electronic health records, to systematically investigate the interactions among these complex factors. The goal is to identify biomarkers and mechanisms associated with disease development across genetic, metabolic, and proteomic dimensions. And figure out the adverse effect of hearing loss, tinnitus and sleep related nero- and cardiometabolic disorders.
Project duration: 36 months
