Pancreatitis (acute or chronic) is a worldwide disease threatening the public health, which is characterized by genetic risk and environmental factors. This research proposal aims to investigate the complex interplay between proteomics, metabolomics, genetic predisposition, and lifestyle factors in influencing the risk and prognosis of pancreatitis. The central research questions are: (1) What molecular signatures (proteomic and metabolomic) are associated with the onset and progression of pancreatitis? (2) How do genetic variants contribute to individual susceptibility and disease outcomes? And whether proteomic and metabolomic factors were modified by genetic risk (interactive effects). (3) In what ways do modifiable lifestyle factors-such as alcohol consumption, smoking, diet, and physical activity-interact with biological pathways to influence disease risk and severity? The primary objective is to integrate multi-omics data with clinical and lifestyle information to identify biomarkers and develop predictive models for pancreatitis risk stratification and outcome forecasting. The scientific rationale lies in the hypothesis that pancreatitis is a multifactorial disease driven by both intrinsic (genetic and molecular) and extrinsic (lifestyle) factors, which interact in a systems-level manner. By adopting a comprehensive, integrative approach, this study seeks to uncover novel mechanistic insights and inform precision medicine strategies for early detection, prevention, and personalized management of pancreatitis. It may take 3 years to finish the project.
