Research Questions!
What are the primary patterns and degrees of cognitive function changes in patients within the first 72 hours, 1 week, and 1 month post-anesthesia?
Do different types of anesthesia lead to distinct differences in the incidence, duration, or severity of post-anesthesia cognitive changes?
What biological and clinical factors are associated with an increased risk of persistent post-anesthesia cognitive impairment?
Objectives!
Identify key risk factors (demographic, clinical, and procedural) that predict the development and persistence of PND.
Provide preliminary evidence to inform clinical strategies for reducing PND risk and improving post-anesthesia cognitive recovery.
Scientific rationale!
PND is a well-recognized complication, particularly common in elderly patients or susceptible populations with pre-existing cognitive impairments. Despite its significant clinical relevance, the pathogenesis of PND remains incompletely understood, and there is no consensus on its risk factors or preventive strategies.
Pive Cognitive Dysfunction (reclinical studies suggest that PND induced by surgery may be associated with inflammatory responses, hypoperfusion embolism, and anesthetic agents.
Furthermore, the demographic shift toward an aging population-accompanied by an increased incidence of comorbidities such as dementia and cardiovascular diseases-has made it more urgent to clarify the pathophysiological mechanisms of PND. This study will fill key gaps: by utilizing data on PND occurrence in postoperative patients from the UK Biobank (UKB) database, we aim to construct a POCD prediction model, conduct further research on its mechanisms, and ultimately improve patients’ postoperative outcomes and quality of life.