We proposes a comprehensive research project leveraging the UK Biobank’s extensive dataset to address critical health challenges faced by our developed societies. This study aims to elucidate the complex interplay between genetic factors, immune system function, and environmental stressors in the development of complex disorders, including lifestyle-related diseases, various cancers, and immune disorders.
At the core of this research is the concept of disease as a dynamic body system interacting with environmental stresses. By utilizing the UK Biobank’s rich repository data, we seek to unravel the intricate pathogenic mechanisms underlying human diseases and translate this knowledge into novel, personalized therapeutic approaches. Our research will employ a multi-layered analysis approach, examining the genome, epigenome, proteins, lipids, cells, and organs at both individual and population levels.
Through advanced statistical and computational analyses of this complex data, we aim to identify key factors that maintain or disrupt body homeostasis. A significant aspect of our study will also involve the development of a robust research platform for human disease. This platform, hosted on a secure server managed by our institution, will be used for 1) Data integration: Combining data from UK Biobank with our corresponding data 2) Cross-Species Analysis: Enabling comparative analysis between human and animal model 3) Establishing standardized data workflows, ensuring reproducibility across different studies. It will facilitate the translation of findings from experimental animal models to humans and vice versa, allowing us to recapitulate and expand our understanding of disease mechanisms identified in human research within mouse models and cell culture systems. This research will form the foundation for developing personalized prevention strategies and targeted therapies, contributing to the realization of stratified medicine for a healthy, long-lived society.
