Degenerative musculoskeletal diseases (DMDs), including osteoporosis, osteoarthritis, degenerative spinal disorders, and sarcopenia, primarily affect the elderly and their incidence is steadily increasing due to the aging population. Chronic pain, commonly associated with these diseases, persists for over three months and is poorly responsive to treatment, significantly impacting patients’ quality of life. Chronic pain not only exacerbates physical disability but also leads to psychological distress, such as anxiety and depression, further affecting cognitive function. While existing research has focused on individual diseases, the interplay between degenerative musculoskeletal diseases, chronic pain, cognitive function, emotional disorders, and lifestyle factors (such as sleep, physical activity, and nutrition) remains inadequately explored. A deeper understanding of these interrelationships is essential for developing effective intervention strategies.
This study aims to explore the associations between degenerative musculoskeletal diseases, chronic pain, cognitive function, emotional disorders, and lifestyle factors (sleep, physical activity, nutrition). The specific objectives are:
To assess the impact of degenerative musculoskeletal diseases and chronic pain on cognitive function and emotional disorders.
To investigate how lifestyle factors, including sleep, physical activity, and nutrition, moderate the effects of diseases on cognitive function and emotional well-being.
To explore the role of biomarkers and genetic factors in the relationship between diseases, emotional, and cognitive disorders.
Public Health Recommendations: Providing evidence-based recommendations for health management of aging populations, particularly focusing on the prevention and treatment of degenerative musculoskeletal diseases and chronic pain.
