Research question
Skin disorders are the most prevalent health conditions globally. Global estimates suggest that the prevalence of skin diseases ranges from 30% to 40%. Traditional treatment drugs are still difficult to fully meet the clinical needs of moderate to severe patients, and safer and long-term treatment methods are needed.
Objective
To achieve precision treatment for skin disorders, this study aims to employ a comprehensive, multi-omics approach, integrating metabolomic, genomic, proteomic, and other omics data from databases. The goal is to identify key risk factors associated with skin disorders and uncover novel potential biomarkers. The findings from this study are expected to contribute to the development of precision medicine strategies for the targeted treatment of skin disorders.
Scientific rationale
Skin disorders involve complex genetic backgrounds and environmental factors, and their diverse clinical manifestations further hinder the prevention and treatment of skin disorders. Existing studies have shown that environmental factors play a role by changing metabolic status and activating immune responses, while genes play a role by determining individual susceptibility to environmental factors, regulating metabolic pathways, and the function of the immune system. Proteins, as key effector molecules, play a bridging role in this process. Psychoneural factors play an important regulatory role in the onset and progression of skin disorders by affecting immunity, metabolism, and skin barrier function. We will combine multi-omics techniques and epidemiological data to explore new risk factors for the disease, identify potential markers, and understand the intricate causal relationships behind skin disorders. This comprehensive study will include atopic dermatitis, psoriasis, urticaria, andneuro-psychiatric diseases associated with anxiety, depression, and insomnia and metabolic diseases with diabetes, obesity, etc.
