Most previous studies focused on examining the individual factor on chronic diseases, which ignored their combined effects or interactions between multi-dimensional genetic and environmental factors. Comprehensive identification of the influencing factors of chronic diseases will help to set up precise intervention strategies to optimize resource allocation. Biomarker plays a crucial role in enhancing understanding of disease mechanisms, improving diagnostic accuracy, evaluating treatment effects, promoting personalized medicine, and assessing environmental exposure. However, there has been limited research conducted on the relationship between biomarkers and a range of phenome-wide disease outcomes. Consequently, the evidence to explore potential role of biomarkers in the complex associations between multi-dimensional genetic and environmental factors with disease is still lacking. The primary purpose of this study is to explore the complex associations (independent, mediation, interaction, joint) of multi-dimensional genetic and environmental factors with risk/ mortality of chronic diseases (cardiovascular disease, cancer, chronic respiratory diseases, diabetes, etc.). This study is expected to last for 36 months. Our research will provide additional evidence on the complex associations of multi-dimensional genetic and environmental factors with risk/ mortality of chronic diseases. Furthermore, we aim to delve into the intricate mechanisms by which multi-dimensional genetic and environmental factors intricately influence biomarkers that underlie the development of chronic diseases. These finding will also provide recommendations for targeted measures to reduce risks and mortality of chronic diseases.
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