Digestive diseases, including inflammatory bowel disease, non-alcoholic fatty liver disease, gastrointestinal cancers, and functional gastrointestinal disorders, are increasingly prevalent worldwide and contribute significantly to morbidity, mortality, and healthcare burden. While prior studies have explored individual risk factors, there remains a critical gap in understanding how multi-omics profiles (genomic, proteomic, metabolomic), diverse environmental exposures (diet, lifestyle), and clinical phenotypes to influence disease onset and progression. Furthermore, emerging evidence suggests that digestive diseases may not occur in isolation but rather share common pathophysiological mechanisms with extra-digestive conditions, including cardiovascular disease, diabetes, and neuroinflammatory disorders. This research seeks to integrate multi-dimensional data to uncover key biomarkers and interaction networks, elucidate potential causal relationships, and examine shared disease pathways. By addressing this question, the study aims to:
1) !!To identify and characterize the integrated multi-omics signatures, environmental exposures, and clinical profiles associated with the incidence and progression of digestive diseases;
2) To elucidate the dynamic interplay and potential causative relationships between key determinants identified in Objective 1 in contributing to the pathogenesis of specific digestive diseases;
3) To investigate potential epidemiological and molecular associations between the digestive diseases and the risk, onset, or severity of non-digestive systemic comorbidities.
