This research aims to replicate and expand on previous NHANES studies by using UK Biobank data to explore several key areas in individuals with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).
First, we will assess the impact of the “weekend warrior” pattern of physical activity on mortality and advanced fibrosis in MASLD. Recent MASLD guidelines recommend 150 minutes of moderate to vigorous physical activity (MVPA) per week but lack evidence on whether concentrated activity (over 1-2 days) offers similar benefits compared to spread-out activity. UK Biobank participants will be classified as weekend warriors, active, or inactive based on their physical activity patterns. We will analyze mortality outcomes while controlling for socio-demographic factors, sedentary behavior, and lifestyle.
Second, we will examine the effect of cardiometabolic risk factors, such as type 2 diabetes and obesity, on advanced fibrosis and mortality in MASLD patients. The rich clinical data in UK Biobank will allow us to stratify risk more precisely and provide stronger evidence for the management of MASLD in patients with multiple risk factors.
Additionally, we will investigate the associations of hand grip strength, dietary patterns, and cognitive function with MASLD outcomes. Hand grip strength will be used as a measure of muscle strength and frailty, potentially influencing disease progression and mortality. Dietary data will shed light on the role of nutrition in MASLD progression, and cognitive function assessments will explore links between neurocognitive decline, MASLD severity, and mortality.
These studies will provide novel insights into the interactions between physical activity, cardiometabolic risks, strength, diet, and cognitive function, aiming to inform personalized treatment and lifestyle interventions for MASLD patients.
