Aims:
This study aims to deepen our understanding of cardiovascular diseases and contribute to developing future therapeutic strategies
-Identification of genetic features associated with cardiovascular diseases in the UK population: The UK Biobank’s data, including basic characteristics, cardiac MRI, and ECG data, will be used to identify genetic markers associated with cardiovascular diseases.
-Comparing the genetic backgrounds of the UK and Japanese populations to elucidate common and distinct genetic factors related to cardiovascular diseases.
-Promotion of personalized medicine: Aim to develop early diagnostic and preventive measures based on genetic features, enabling the identification of individuals at high risk.
-Development of new therapeutic strategies: The identified genetic markers will be used to discover new therapeutic targets, contributing to the advancement of cardiovascular disease treatments.
Scientific Rationale:
Cardiovascular diseases are known to have a significant genetic component. Previous studies have identified specific genetic variants that increase the risk of developing cardiovascular diseases, but these findings have primarily focused on Western populations. This study will utilize the UK Biobank’s extensive dataset, including data from 500,000 participants. We will use cardiac MRI data to assess heart function and ECG data to detect arrhythmic events. A statistical analysis will investigate the genotype-phenotype relationship in cardiovascular diseases. A genome-wide association study (GWAS) will also be conducted to identify genetic markers associated with cardiovascular diseases in the UK population. Additionally, we will compare these findings with genetic data from the Japanese population to elucidate both shared and distinct genetic backgrounds. This research aims to deepen our understanding of cardiovascular diseases and contribute to developing future therapeutic strategies.
