The major adverse cardiovascular events during hospitalization have a significant impact on disease prognosis and mortality. Every year, the number of registered cases of adverse cardiovascular events among hospitalized patients increases. Identification and prediction the occurrence of cardiovascular adverse events is one of the main goals of sustainable development. Investigation of risk factors for major adverse cardiovascular events (such as acute myocardial infarction, ventricular fibrillation, acute coronary syndrome, acute heart failure, cardiac arrest and so on) is a milestone toward the development of prevention strategies. Such programs may reduce the burden of non-communicable diseases. In the last years, several markers of preclinical cardiovascular disease have been proposed to refine the identification of subjects at higher risk to be enrolled in more aggressive prevention programs. However, the long run of cardiovascular risk prediction that started with the identification of “classical” risk factors is far from over. Therefore, our team would like to investigate the association of extra potential risk factors with the major adverse cardiovascular events in hospitalized patients in order to provide more refinement in early identification and prediction. If the risk factors are confirmed, we ‘d like to undertake further tests to confirm their significance. Identifying the more risk factors could be a critical initial step in identifying people with a poor prognosis from those illness and then potentially developing more refined treatment.