Scientific rationale:
Digestive system cancers (DSC) pose a substantial global health burden, representing over 25% of cancer-related mortality worldwide. DSC encompass histologically diverse entities, with esophageal adenocarcinoma, gastric signet-ring cell carcinoma, and colorectal adenocarcinoma representing predominant subtypes exhibiting substantial genomic instability.Dynamic evolution is characterized in digestive tumors, especially in terms of genomic instability of tumor cells. The application of multi-omics technology has shown great potential in the study of digestive system tumors, especially in revealing the molecular mechanisms of tumorigenesis. By integrating multiple omics data from radiomics, genomics, transcriptomics, proteomics, and metabolomics, researchers can more fully understand the complex biology of tumors. The integration of multi-omics technology not only improves the understanding of the mechanism of digestive system tumorigenesis but also provides a basis for the development of personalized treatment strategies.
Research Question:
The dynamic evolution of digestive system tumors involves a variety of biological mechanisms, including gene mutations, epigenetic changes, and microenvironment interactions. However, the key drivers of tumor dynamic evolution are not well understood. Tumor metastasis is one of the important reasons for the poor prognosis of patients with digestive system tumors, and in-depth study of its mechanism is helpful for discovering new therapeutic targets.
Objective:
1. Identify the genomic characteristics of digestive system tumors and their relationship to tumorigenesis and progression.
2. Analyze the transcriptome characteristics of digestive tumors and reveal differences in the expression of key genes.
3. To explore the multi-omics characteristics of the metastasis mechanism of digestive system tumors, and to provide new ideas for targeted therapy.