The metabolic syndrome (MetS) is a cluster of the most dangerous heart attack risk factors: diabetes and prediabetes, abdominal obesity, high cholesterol and high blood pressure. It affects around 20-25 percent of adults in the world. Previous studies have observed associations between MetS and cancer development and cancer-related deaths. However, it’s still unclear which MetS components are more harmful, and whether the harmful effect are additive. For MetS and risk of certain site-specific cancer, the current evidence is still unclear. We therefore proposed this study to comprehensively evaluate MetS and cancer. We have three aims:
1. To investigate the MetS and subsequent overall and site-specific cancer risk/death
2. To investigate individual components of MetS and cancer risk/death
3. To investigate the interaction of individual components of MetS, in relation with cancer risk/ death
This is a 2-year project. We will carry out a comprehensive analysis of MetS and cancer risk. The results will provide robust evidence for the management of MetS as well as the development of cancer prevention strategies.