Our research project aims to understand how neurodegenerative diseases, specifically Parkinson’s disease (PD) and Huntington’s disease (HD), affect the structure of the brain, particularly human neurodegeneration diseases related to the striatum.
We will be using advanced brain imaging analysis methods to examine the microstructure of the brain in individuals with these diseases. By studying the patterns of brain changes, we hope to gain insights into how these diseases develop and progress over time.
In addition, we will be investigating is the influence of genetic factors on the manifestation of symptoms and clinical parameters in subjects with these diseases. We want to understand how specific genetic variations may affect the progression and severity of the diseases.
To conduct this research, we will utilize a large dataset of imaging data and other information from the UK Biobank. This will allow us to analyze the brain images of a large number of individuals and correlate the findings with their genetic and clinical profiles and disease progress.
The findings from this research have the potential to have a significant impact on public health. By uncovering the structural changes in the brain associated with PD and HD, we can deepen our understanding of the underlying mechanisms of these diseases. This knowledge can help in the development of better diagnostic tools and personalized treatments.
Furthermore, we hope to identify specific biomarkers that could serve as indicators of disease progression or potential targets for therapeutic interventions. Early detection and intervention are crucial for improving outcomes and quality of life for individuals with neurodegenerative diseases.