The incidence of tumor diseases is increasing year by year, which has become an increasingly serious public health problem worldwide. With the deepening of tumor biology, genetics and epidemiology, there is a growing recognition of the role that lifestyle plays in tumorigenesis and progression. Some studies have proposed that healthy eating habits may reduce the risk of some types of tumors. In addition, immune function biomarkers also play important roles in the development of tumor. Therefore, the specific mechanisms by which lifestyle and immune function biomarkers influence tumor development remain to be further explored.
To address this research gap, this study intends to utilize an integrated approach, combining a wide range of genetics, metabolomics, proteomics, and comprehensive epidemiological data. Through multidimensional analysis, this study aimed to investigate the relationship between lifestyle factors and immune function biomarkers in patients with oncology diseases.
Oncological diseases, including glioma, pituitary tumor, are increasingly associated with immune dysregulation in their pathogenesis and progression. Lifestyle factors are known to influence immune function and may significantly modulate disease progression. Despite these advances, the precise mechanisms linking lifestyle factors, immune function, and neoplastic disease outcomes remain largely unexplored. The UK Biobank (UKB) with extensive multi-omics data, including genetic, metabolomics and proteomic profiles, provide a unique opportunity to clarify these complex relationships.
To explore these relationships, this study aims to leverage the comprehensive UKB database, which includes whole genome sequencing, imaging data, lifestyle and environmental factors, medical records, and clinical scale assessments. Integrating multi-modal data will identify key lifestyle factors associated with immune biomarkers and tumor disease progression.
