Research question:The prevalence of central nervous system (CNS) diseases continues to rise annually, presenting a significant challenge due to their high disability rates, which profoundly impact patients’ quality of life and contribute to a growing societal burden. The need for effective strategies to prevent or slow the progression of these diseases has never been more urgent, highlighting the importance of ongoing research. Lifestyle factors play a crucial role in the onset and progression of CNS diseases. However, the effects of similar lifestyle habits may vary across different conditions. Furthermore, the exact mechanisms by which lifestyle factors influence disease outcomes remain unclear and warrant further investigation.
Objective:To address this research gap, the present study intends to utilize an integrated approach, incorporating extensive genetic, metabolomic, proteomic, and comprehensive epidemiological data. Through multidimensional analyses, the study aims to investigate the association between lifestyle factors and immune function biomarkers in patients with CNS diseases, explore the role of immune function in mediating the relationship between lifestyle and disease onset and progression, and identify potential lifestyle interventions that may modulate immune responses to improve clinical outcomes in CNS diseases.
Scientific rationale:Central nervous system (CNS) diseases, including Parkinson’s disease (PD), Alzheimer’s disease (AD), and cerebrovascular disease, are increasingly recognized to involve immune dysregulation in their pathogenesis and progression. Lifestyle factors such as diet, exercise, and stress management are known to influence immune function and may significantly modulate disease progression. However, the mechanisms linking lifestyle, immune function,
