Questions
1. How do common diseases-including psychiatric disorders, cancer, cardiovascular disease, and diabetes-interact with multiple organ systems?
2. What are the shared genetic, molecular, and environmental factors that link these diseases across different organ systems?
3. How do systemic changes in one organ influence disease risk, progression, and comorbidities in others?
Objectives
1. Identify multi-organ interactions: Utilize large-scale genomic, transcriptomic, and biomarker datasets to investigate the biological crosstalk among key organ systems (e.g., brain, cardiovascular, metabolic, immune, and gastrointestinal systems).
2. Uncover shared pathophysiological pathways: Examine common mechanisms such as chronic inflammation, oxidative stress, metabolic dysregulation, and immune dysfunction that contribute to disease comorbidities.
3. Determine causal relationships: Apply Mendelian Randomization (MR), structural equation modeling (SEM), and polygenic risk score (PRS) approaches to evaluate causal links between organ dysfunction and disease development.
4. Clinical and therapeutic implications: Identify systemic biomarkers for early disease detection and assess multi-organ intervention strategies that may improve disease prevention and treatment.
Many common diseases, including psychiatric disorders, cancer, cardiovascular disease, and diabetes, do not operate in isolation but instead involve complex interactions across multiple organ systems. Increasing evidence from genomics, epigenetics, and functional studies highlights the importance of a multi-organ approach in understanding disease mechanisms. By integrating data across multiple diseases and organ systems, this study aims to reveal shared biological pathways, identify novel therapeutic targets, and improve precision medicine approaches for complex diseases.
