Current evidence suggests that cumulative effects of environmental, behavioral, and healthcare-related exposures may influence the comorbid progression of cancer and cardiovascular systems through systemic biological responses. However, critical knowledge gaps persist in identifying key exposure determinants and their cross-disease regulatory mechanisms. Elucidating these association patterns will provide novel insights for risk stratification and precision prevention.
This study addresses the central scientific question: “What exposure characteristics are potentially associated with the incidence and prognosis of cancer and cardiac diseases?” Leveraging the extensive data resources of the UK Biobank, a three-year population-level investigation will be conducted. The project will integrate environmental exposure profiles (e.g., pollutant contact, residential characteristics), behavioral patterns (dietary habits, physical activity levels), medical exposure profiles, etc. to establish an analytical framework for exposure-disease associations in cardio-oncology.
First, we’ll assess exposure sets linked to cardiovascular and cancer risk, focusing on their impact and interactions. Next, we’ll quantify the risk of key exposures on clinical outcomes and explore their combined effects with genetic and phenotypic factors. Our goal is to create a comprehensive risk model to identify intervention targets and guide prevention strategies based on specific population risks.
This study will comprehensively identify key factors in cardio-oncology, shifting clinical practice from treatment to risk management. It establishes a framework for interdisciplinary prevention, aiming to reduce cancer and cardiac disease burdens, supporting public health goals by managing preventable exposures and risks.
