We will impute brain-related metabolite data into the UK Biobank sample and correlate the reconstructed metabolite levels with available phenotype data. Identification of a link between neuro-metabolite and trait measure is likely to result in the discovery of a biomarker, which in turn may yield novel biological insights.
We will use the genetic component of metabolite levels in cerebrospinal fluid (CSF) determined by an individual’s genetic profile and correlate the reconstructed metabolite levels with available phenotype data in the UK Biobank. Identification of a link between neuro-metabolite levels and specific phenotypes is likely to result in the identification of candidate biomarkers for brain-related traits (and disorders), which in turn may yield novel biological insights. The CSF metabolite data is obtained from an independent project in which the genetic regulation of brain metabolites is studied.
