This study aims to investigate the genetic and multi-omics differences between infectious heart diseases and non-infectious heart diseases. The study aims to achieve the following goals:1) Identify genetic variants associated with infectious and non-infectious heart diseases through genome-wide association studies and polygenic risk scores.2) Integrate genetic data with cardiac imaging, electrocardiogram, accelerometer data, and associated medical records to explore multi-omics biomarkers and pathophysiological differences.3) Investigate the overlap or differences in genetic risk factors between common cardiovascular diseases and sepsis-related heart diseases (including sepsis-induced myocardial injury).4) Evaluate the potential clinical significance for risk stratification, prevention, and targeted treatment.Extensive research has shown that non-infectious cardiovascular diseases (CVD) are primarily driven by atherosclerosis and lifestyle factors. However, infectious heart diseases may involve distinct genetic predispositions and pathophysiological mechanisms. Among them, etiologies include direct infection and septic cardiomyopathy-a complication of sepsis characterized by acute, reversible myocardial dysfunction, with an incidence of up to 40-50% in sepsis patients, significantly increasing mortality. Septic cardiomyopathy involves immune hyperactivation, mitochondrial dysfunction, and microvascular injury, and may be influenced by specific genetic susceptibilities. Currently, genetic studies on septic cardiomyopathy remain very limited, highlighting an urgent need for large-scale genomic comparisons between infectious and non-infectious heart diseases.
